ZEISS Announces Revolutionary New Microscopy Technology for Life Sciences
On Thursday, 6 March 2025, ZEISS, a leading global technology company in the optical and optoelectronic industry, announced the launch of Lightfield 4D, an innovative microscopy technology that captures physiological and neuronal processes in 3D. This breakthrough technology, integrated into the new ZEISS LSM 910 and LSM 990 confocal microscope systems, is set to revolutionize the way researchers observe living organisms.
Lightfield 4D utilizes the light-field principle to enable high-speed fluorescence imaging, gentle long-term observation of living organisms, and accelerated data collection on large samples. It allows for instant volumetric high-speed imaging, providing researchers with unprecedented temporal resolution to study the dynamic processes of life in complete samples.
This new technology addresses the critical need for 4D imaging, which combines volume and time to truly understand biological processes. Traditional optical sectioning techniques have long struggled with the limitations of sequential image acquisition, resulting in time delays and compromised spatiotemporal accuracy of data. Lightfield 4D overcomes these challenges by capturing entire 3D data sets at a precise moment in time, eliminating time delays within a captured volume.
The innovative technology utilizes a micro lens array to generate 37 individual images simultaneously, capturing comprehensive 3D information in real-time. This approach allows for the creation of Z-stacks through advanced deconvolution-based processing, achieving an impressive rate of up to 80 volume Z-stacks per second. This provides insights into rapid biological events, such as physiological and neuronal processes.
In addition to its speed, Lightfield 4D also offers the benefit of gentle imaging. By capturing a complete Z-stack in one illumination event, it reduces light exposure and phototoxic effects, allowing for long-term imaging of entire living organisms. Its unmatched speed also facilitates the capture of multi-color volumes of large samples, enhancing the productivity of experiments across various applications.
Dr. Bernhard Zimmermann, Head of Life Sciences Microscopy at ZEISS, says, “Combining volume and time to enhance our understanding of complex biological processes, ZEISS Lightfield 4D represents a leap forward in 4D imaging.” He adds, “We believe that Lightfield 4D will redefine the imaging landscape. This innovative system empowers researchers to capture biological processes in real-time, providing unprecedented insights into the dynamic nature of life.”
To complement the launch of Lightfield 4D, ZEISS also introduces enhanced versions of its LSM platforms: ZEISS LSM 910 and LSM 990. These upgraded systems feature new high-bandwidth electronics that support beampath technology for exceptional light preservation, visualization of high dynamic ranges, and a broad wavelength bandwidth. Additionally, image quality improvements with ZEISS Airyscan jDCV are now available for all Airyscan Multiplex modes. The Microscopy Copilot, a personal AI assistant, also helps researchers explore new possibilities for their imaging experiments.
For more information on ZEISS Lightfield 4D, please visit: https://zeiss.ly/nw-lightfield-4d
For press inquiries, please contact:
ZEISS Research Microscopy Solutions
Vybhav Sinha
Email: press.microscopy@zeiss.com
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